Critical care hospitalisation for COVID among people with asthma, multiple sources

CRITICAL CARE:
– When hospitalised for COVID, people with asthma are more likely to receive critical care than people without underlying respiratory condition. (1)(2)
– There is an indication, although not statistically significant, that PWA have an increased risk of hopitalisation and critical care (ICU admission and ventilator use) compared to people without asthma.(3)
– Adults with asthma that have a history of asthma attack in the preceding 2 years (defined as two or more courses of oral corticosteroids (OCS), or at least one previous asthma hospitalisation) have an increased risk of ICU admission or death, compared with COVID patients without asthma (adjusted HR between 1.44 and 1.27 for history of OCS; adjusted HR = 2.24 for history of asthma hospitalisation, compared to patients without asthma). Suplementary material (table S7): the risk of ICU admission was higher in patients with a history of one or more course of OCS (adjusted HR 1.23 to 1.89) and in patients with a history of asthma hospitalisation (adjusted HR 3.48) compared to patients without asthma. (4)

in hospitalised (severe COVID) patients: (1)
A large prospective cohort study reported that amongst patients hospitalised with COVID, asthmatic patients aged 50 and over that used ICS within 2 weeks before hospitalisation were 14% less likely to die than patients without chronic respiratory conditions.

Categories: COVID
Author: Agnes
Entry Date: 4/2/2022
Source 1 Name: Bloom CI, Drake TM, Docherty AB, Lipworth BJ, Johnston SL, Nguyen-Van-Tam JS, et al. Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. Lancet Respir Med. 2021;9(7):699-711.
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Source 2 Name: Impact of COVID-19 on asthma: Rapid Review for Asthma Australia. The George Institute for Global Health; 2020
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Source 3 Name: Sunjaya AP, Allida SM, Di Tanna GL, Jenkins CR. Asthma and Coronavirus Disease 2019 Risk: a systematic review and meta-analysis. European Respiratory Journal. 2021:2101209.
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Source 4 Name: Shi T, Pan J, Vasileiou E, Robertson C, Sheikh A; Public Health Scotland and the EAVE II Collaborators. Risk of serious COVID-19 outcomes among adults with asthma in Scotland: a national incident cohort study. Lancet Respir Med. 2022 Jan 13:S2213-2600(21)00543-9. doi: 10.1016/S2213-2600(21)00543-9. (incl Suppl.)
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